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The active ingredient Aripiprazole is one of the main drugs used to treat schizophrenia and mania. He was admitted in 2004 and is now used frequently. As “atypical antipsychotic” Aripiprazole is considered better tolerated than the older, “classical” neuroleptics. The active ingredient can lead in rare cases to weight gain. Nursing mothers and pregnant women should take Aripiprazole only after consultation with the doctor. Here you can read everything about Aripiprazole.
How Aripiprazole acts
In the brain and spinal cord (central nervous system) ensures the interaction between different neurotransmitters that make you feel balanced and appropriate to certain situations (such as excitement, joy, etc.) can react. Given the various messengers (such as serotonin and histamine) distributed according to need of nerve cells and later resumed and stored.
This balance of neurotransmitters is common in people who suffer from schizophrenia or bipolar disorder, disturbed. The thoughts and perceptions of those affected are greatly changed. By disturbed sense of self and different type of behavior, it is virtually impossible to cope with everyday life without assistance.
The active ingredient Aripiprazole belongs to the group of medicines called “atypical antipsychotics”: It blocks certain docking sites (receptors) of histamine and simultaneously activates receptors of serotonin. This restoration of the neurotransmitter equilibrium leads to serenity and sentiment.
Up, degradation and excretion of Aripiprazole
The drug is usually administered by mouth and then taken up almost entirely from the intestine into the blood. The reduction takes place in the liver. Because the drug accumulates in the body tissue, it can take up to a month until everything Aripiprazole was excreted from the body.
When will Aripiprazole used?
Among the areas of application (indications) of Aripiprazole include:
- treatment and prevention of manic episodes in a so-called bipolar disorder
How Aripiprazole is applied
Normally the substance is applied Aripiprazole in the form of tablets, orodispersible tablets or solutions for absorption via the mouth (oral). In acute cases, but it can also be injected directly into the muscle.
The dosage in adults is 10 to 30 milligrams per day, the dosage for each patient should be determined individually.
The effect usually occurs only after a few weeks.
What are the side effects of Aripiprazole?
Often, that is, at one to ten percent of those treated, causes Aripiprazole side effects such as restlessness, insomnia, gastrointestinal discomfort, dizziness and blurred vision. In addition, there are often a so-called “extrapyramidal disorder” with symptoms such as tremor, shuffling while walking, motor restlessness and muscle weakness.
Occasionally, (less than one percent of people) rapid pulse and low blood pressure. Besides, it can occasionally be a lack.
What to consider when taking Aripiprazole?
Patients with cardiovascular disorders and convulsions () should take medications Aripiprazole with caution.
It has been suggested that Aripiprazole may increase the risk of occurrence of gambling addiction.
In concurrent use of other drugs may lead to strong interactions.
Aripiprazole enhances the effects of agents against and from centrally acting drugs (such as antidepressants or strong painkillers). This applies in particular in combination with alcohol.
Some drugs intensify the effect of Aripiprazole. Thus, the physician should reduce the Aripiprazole dose with concurrent use of the following:
- quinidine (for arrhythmia)
- ketoconazole and itraconazole (for fungal infection)
- Fluoxetine, Paroxetine and esCitalopram (for depression)
- for HIV (such as indinavir, ritonavir, atazanavir or lopinavir)
- Diltiazem (in coronary heart disease, arrhythmia or blood pressure)
The following substances decrease when coadministered the Aripiprazole effect:
- Carbamazepine, Phenytoin, phenobarbital and primidone (used to treat seizures)
- rifampicin, rifabutin (antibiotics)
- efavirenz, nevirapine (for HIV)
- St. John’s Wort (for mild depressive moods)
Driving and using machines
Because of the central effects of Aripiprazole, there may be a slower reflexes in the treated. Therefore, it should be taken just at the beginning of the therapy to the individual tolerance and initially not participated actively in use on the road.
For use of Aripiprazole in children are only a few data are available. Children and adolescents under 15 years should therefore be given the drug only after strict medical benefit-risk assessment.
In elderly patients (65 years) has not been demonstrated in clinical trials Aripiprazole’s efficacy. What is the individual benefit of treatment with Aripiprazole in such a case, the patient must be evaluated by the treating physician.
Pregnancy and lactation
The scope of experience on the use of Aripiprazole in pregnancy and lactation is not very high. Before taking any medication Aripiprazole should therefore be assessed against the benefits of the individual risk by the treating physician.
How to obtain drugs with Aripiprazole
medications Aripiprazole are available by prescription and is therefore only available with a doctor’s prescription in the pharmacy.
Since when Aripiprazole is known?
The active ingredient Aripiprazole comes from the new generation of drugs for psychosis (atypical antipsychotics). This solves in comparison to the older generation of antipsychotics less frequently from a so-called extrapyramidal disorder. Furthermore, should at the newer generation – significantly improves the so-called negative symptoms of schizophrenia (such as changes in self-perception, depression and slowed motor skills) – as opposed to the older drugs. However, the atypical neuroleptics of the new generation often lead to weight gain.
Overall, it is critically discussed by experts, whether the antipsychotics of the second generation as Aripiprazole the older drugs are truly superior. It remains to be seen how to position the new active substances.