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The active ingredient Benazepril is a so-called ACE inhibitors. It is used to treat high blood pressure (hypertension) and heart failure (congestive heart failure). As with other antihypertensives, the active ingredient increases lead to initiation of therapy to dizziness, weakness and malaise. Here you can read everything worth knowing about Benazepril: action, application and side effects
How Benazepril acts
One of the most important blood pressure-regulating systems in the human body is the so-called renin-angiotensin system (RAAS). It is a complex structure for controlling and fine regulation of blood pressure. This is vital, because a too high blood pressure damages the organs and too low leads to oxygen and nutrient deficiency of tissue.
The central site for measurement of blood pressure in the kidneys RAAS are: Are they blood flow decreases, they release the enzyme renin from increased, with increased blood flow less. Renin ensures that from a precursor the hormone angiotensin I is produced. Angiotensin I is then the enzyme “angiotensin converting enzyme” (abbreviated ACE), which is found in the lungs and the kidneys, is converted into another chemical messenger:. Angiotensin II This can raise blood pressure by constricting the blood vessels and the water and salt excretion decreased in the kidneys.
ACE inhibitors like Benazepril block the enzyme ACE. Thus, a rise in blood pressure is prevented. Desired and necessary it is for people with high blood pressure: For a permanently elevated pressure (above 140/90 mmHg) damages the blood vessels. This can have serious consequences such as stroke, heart failure and severe damage to eyes and kidneys after itself.
Even with heart failure is a decrease in blood pressure sense because so that the heart is relieved.
Up, reduction and elimination of Benazepril
After his capture of the active substance passes quickly through the intestines into the blood, where it reaches its highest level after 30 minutes. Since Benazepril is a precursor of the active substance Benazeprilat, the drug must first be activated in the liver. The active drug achieved after 90 minutes their highest blood levels. After ten to eleven hours, the half of the active substance is excreted or degraded to another, non-active substances. Excretion is mainly via the kidneys in the urine.
When will Benazepril used?
The active ingredient Benazepril is approved for the treatment of:
- essential hypertension (without apparent cause)
- heart failure (congestive heart failure)
In more severe cases of heart failure, Benazepril is usually combined with diuretics (diuretics) or digitalis.
The taking Benazepril must be long term, as the drug improves the symptoms but does not cure the underlying disease.
How Benazepril is applied
The ACE inhibitor Benazepril is taken as a tablet in the morning with or without food. In hypertension, treatment is usually started with a loading dose of ten milligrams of Benazepril. The dosage may then be gradually increased up to 40 milligrams. In heart failure, the initial and maximum dose are lower (at 2.5 milligrams or 20 milligrams). Was the blood pressure remained stable with the drug for some time, will be switched to a maintenance dose of usually ten milligrams of Benazepril.
a possible salt or volume depletion should be corrected prior to initiation of treatment, otherwise the drop in blood pressure at the start of therapy can vary excessively.
Can not Benazepril reduced in the high-dose blood pressure sufficiently, most patients will also receive other blood pressure medications.
What are the side effects Benazepril?
At the beginning of therapy with Benazepril leads to weakness and often, especially when getting up from a sitting or lying position. The reason is that the patient has to get used to the unusual low, but normal blood pressure.
With a ten to one hundred Benazepril patients develop renal dysfunction, an inflammation of the bronchi, dry cough, nausea, indigestion, fatigue and altered blood values. Especially the dry cough should be communicated to the physician, since this may be a sign that Benazepril is not tolerated.
What should be considered when taking Benazepril?
The active ingredient Benazepril may cause interactions in combination with other active ingredients, although such preparations to a different time of day to be taken.
Other antihypertensives, and drugs that reduce only as a side effect of blood pressure (such as antidepressants, anti-angina and alcohol), the effect of Benazepril may increase unpredictably.
So-called NSAIDs (non-steroidal anti-inflammatory) may reduce the effect of Benazepril. In addition, they may increase the nephrotoxic side effects. NSAIDs are painkillers and anti-inflammatories, which are applied as in rheumatism, inflammation and general pain (such as headaches). It belong to, for example, aspirin (acetylsalicylic acid), Diclofenac, Indomethacin and Naproxen.
In the simultaneous intake of drugs that affect potassium levels, this should be closely monitored. Examples include potassium supplements, some drainage means (Spironolactone, eplerenone, amiloride, triamterene) and the anticoagulant heparin.
Some active ingredients can change (as a side effect) the blood picture, such as the white blood cell count. Combined with Benazepril may increase the likelihood for it. Such agents include anti-cancer agents, immunosuppressive agents (drugs that suppress the immune system), glucocorticoids (“cortisone”) and gout remedies.
By Benazepril the hypoglycemic effect of diabetes medications may increase (oral glucose-lowering drugs and insulin blood). At the beginning of Benazepril therapy Diabetics should therefore increasingly measure their blood sugar levels.
pregnant, nursing mothers and children should not be treated with antihypertensives Benazepril.
How to obtain drugs with Benazepril
The active ingredient is Benazepril in each dose prescription and prescription. One thus gets him only with a doctor’s prescription in the pharmacy.
How long Benazepril is known?
The ACE inhibitor Benazepril is an evolution of the first ACE inhibitor Captopril. This in turn is a chemical derivative of a substance in the venom of the Brazilian Bothrops jararaca. In contrast to Captopril, Benazepril has a longer duration of action in the body and does not cause taste discomfort. Preparations containing the active substance Benazepril were registered in Germany in 1996. ‘/ P>