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Clomipramine is used to treat depressive disorders in obsessive-compulsive disorder and chronic pain conditions. Unlike everyday is in depression a frequent and severe disease. To date, the cause is not known. There are strong indications that the interplay between the various neurotransmitter – is disrupted in the brain – chemicals that transmit nerve signals. Because the symptoms can be relieved by drugs that enhance the effect of some neurotransmitters – here are mainly the neurotransmitters serotonin and norepinephrine call. Clomipramine belongs to the drug group of tricyclic antidepressants: antidepressant drugs with similar chemical structure. It occupies the binding sites for various brain neurotransmitters and thereby alter the influence of these neurotransmitters in brain metabolism. In particular, it blocks transport substances after signal transmission back carrying serotonin back into the memory slots. Serotonin remains longer at the site, and its effectiveness rises. Clomipramine acts mood enhancing, easy drive-enhancing and anxiolytic. Involuntarily recurring and often perceived as distressing thoughts or actions as a sign of obsessive-compulsive disorder can be reduced or prevented by Clomipramine. The anxiolytic and drive increasing effect usually occurs very quickly, while the mood enhancing effect does not begin until after about two weeks. For chronic pain the processing of pain signals in the brain is often disturbed. The neurotransmitter serotonin probably plays a major role in the construction of a filter for incoming pain signals. Treatment with Clomipramine may possibly replace the constant use of painkillers. The drug must be taken regularly for a long time.