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The active ingredient Dimenhydrinate is one of the drugs most commonly used to treat nausea and vomiting on trips (sea or motion sickness). The most common side effects often occur fatigue and drowsiness. Here you can read everything you need to Dimenhydrinate: application, effects, interactions and side effects
How Dimenhydrinate acts
Dimenhydrinate is an anti-emetic, so a remedy for nausea and vomiting. It is chemically considered connecting two separate particles before: Diphenhydramine and chloroTheophylline. The latter is (similar to caffeine) was added as a mild stimulant to alleviate the fatigue commonly encountered after administration of Diphenhydramine. The actual effect against nausea traveling unfolds Diphenhydramine.
The brain collects an ongoing information from the environment by using the various sensory organs. Developmentally very old brain functions often run together in the brain stem, as well as the evaluation of the position of the body in space and its movement. If you sit in a vehicle, but the brain sees the movement, feels about the inner ear at a constant speed no acceleration and also the muscles Report no movement. These contradictory information causes the brain stem, call an alarm program, which manifests itself in malaise, nausea and.
The active ingredient Dimenhydrinate passes through the bloodstream to a region on the back of the brain stem, which is called “area postrema”. There are many docking stations for neurotransmitters (acetylcholine and histamine, among other things), and toxins from the blood that cause nausea and vomiting. Dimenhydrinate blocked this docking and so mediates its effect which alleviates nausea and vomiting.
After taking Dimenhydrinate passes through the intestine into the bloodstream. About the liver, it is broken down after an active period of three to six hours and is excreted through the kidneys in the urine.
When will Dimenhydrinate used?
The active ingredient Dimenhydrinate is used to prevent and treat nausea and vomiting of various origins – but especially when – approved. For the treatment of nausea caused by chemotherapy is not appropriate.
The intake without medical prescription should only be carried out shortly before and during the trip.
How Dimenhydrinate is applied
In the self-medication Dimenhydrinate is taken in the form of tablets or chewing gum. Usually a single dose contains 50 milligrams Dimenhydrinate. To prevent a tablet or a chewing gum for half an hour before departure and then up to three times a day is taken. If nausea or vomiting during the trip on, one to two tablets are taken every four hours, but not more than six tablets (equivalent to 300 mg Dimenhydrinate) per day. When taking larger amounts of the drug can lead. Therefore, it is also called “Dimenhydrinate Drug” is misused, but only from doses above 400 milligrams.
What are the side effects of Dimenhydrinate?
The taking Dimenhydrinate also leads many travel sick to fatigue and drowsiness, but this effect may also be desired at times.
In a hundred to a thousand patients, it also comes to side effects such as restlessness, agitation, troubled or exuberant mood, movement disorders, dizziness, convulsions, urination problems, vision problems and allergic reactions with skin rashes and itching. In allergic symptoms taking may not be continued.
What should be considered when taking Dimenhydrinate?
The combined intake with other agents, although this takes place at different times can lead to interactions.
If Dimenhydrinate in combination with centrally acting drugs (psychotropic drugs) or alcohol, the depressant or stimulant action can be increased.
Antihypertensive drugs act under certain circumstances stronger if additional Dimenhydrinate occupied. The intake should be previously discussed with the doctor.
Dimenhydrinate attenuates the effect of anticoagulants such as heparin and the anti-inflammatory effect of glucocorticoids (“cortisone”).
The active ingredient Dimenhydrinate can be applied in a reduced dose in children aged six years. Older patients can be treated with Dimenhydrinate – unless they are suffering from elevated intraocular pressure (glaucoma, glaucoma), epilepsy or an enlarged prostate. Pregnant and lactating women may also not take Dimenhydrinate.
How to obtain drugs with Dimenhydrinate
preparations with Dimenhydrinate for ingestion (such as tablets, chewing gum and capsules with delayed drug release) and suppositories (suppository) is apothekenpflichtig and can be purchased without a prescription.
preparations for injection are available by prescription. The same is true for combination preparations with prescription drugs.
Since when Dimenhydrinate is known?
In the 1940s, anti-allergic agents (antihistamines) came on the market, but they all had severe fatigue as a side effect. With the combination of Diphenhydramine and chloroTheophylline the pharmaceutical company GD Searle and Company in the US reached its first formulation, which resulted in less fatigue. In the first tests on patients with hives were discovered by chance that Dimenhydrinate help against motion sickness. End of the 1940s then the new drug came out with the active substance Dimenhydrinate in the US and in Germany on the market.