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Doxazosin is an alpha-1 receptor blockers. He helps a benign enlarged prostate (benign prostatic hyperplasia = BPH) and can also be used for treating high blood pressure (hypertension). The active ingredient is broken down and excreted, so a daily dose generally sufficient only slowly. Read more about the application, effects and side effects of Doxazosin.
So Doxazosin acts
The active ingredient Doxazosin binds only to so-called alpha-1 receptors. Are the binding sites in the nervous system, in the salivary glands and on the muscles of the blood vessels and many organs. Busy of drug receptors, these are blocked for other accreting here messengers. These include, for example, adrenaline and noradrenaline.
Such messengers in the body ensure that, for example, the heartbeat increases or the smooth muscle of organs and arteries changes its voltage. Smooth muscle cells are, among other things at the bladder neck, in the urethra and prostate. Pull yourself together, the lower urinary tract narrowing. The drug can reverse this narrowing, so that in particular patients with an enlarged prostate can be easily water.
Also in the wall of blood vessels sit alpha-1 receptors. The body’s own neurotransmitters such as noradrenaline narrow the diameter of the blood vessels – the arteries stretch so together. Thereby, the blood pressure rises. Blocked Doxazosin here the Alpha-1 receptors, the arteries dilate again and the blood pressure drops.
When will Doxazosin applied?
Doxazosin is used to treat and benign enlarged prostate ,
So Doxazosin is applied
Doxazosin is a tablet with various drug concentrations. If the symptoms of benign enlarged prostate or high blood pressure treated, is usually sufficient, a tablet with 4 milligrams (mg) of active ingredient per day. Depending on requirements, the amount of active ingredient can be doubled up to 8 mg. The effect lasts for a long time, which is why Doxazosin should be taken only once a day.
Doxazosin passes through the intestine into the bloodstream. There, the agent binds to certain proteins in the blood plasma. The concentration in the blood reached after six to eight hours maximum. The degradation of the active ingredient found in the liver rather than the metabolites are excreted in the stool.
What are the side effects of Doxazosin?
Common side effects of Doxazosin are infections of the urinary and respiratory tract. Also drowsiness, nausea, vomiting, or heartburn possible.
Occasionally, facial swelling (edema), rash during treatment arise. Also insomnia and depression are possible.
Very rare symptoms such as blurred vision, cramps of the bronchial muscles (bronchospasm), jaundice (jaundice) or a reduced number of white blood cells (leukopenia) have been reported.
If the side effects mentioned or not mentioned complaints reoccur in connection with the application of the drug, you always discuss with your doctor whether you can the drug continue to take or should obtain a replacement drug.
When should not you are taking Doxazosin?
You should not take Doxazosin if you have had an allergic reaction to the active substance or related substances. Patients with a chronic urinary tract infection, of hepatic impairment or pathologically narrowed esophagus must the drug only under close medical supervision to apply.
can unfold interact with the following:
- other alpha blockers (unwanted hypotension, increased heart rate)
- antihypertensive agents such as Enalapril (uncontrolled hypotension)
- PD-5 inhibitors, ie potency enhancing drugs such as sildenafil, tadalafil (uncontrolled hypotension)
During pregnancy and lactation the drug should not be used because the effect on the fetus and the neonate is not sufficiently investigated. If a therapy nevertheless be necessary, this is previously clarified with your gynecologist.
How to receive medication with Doxazosin
medication with Doxazosin are available by prescription and only against a doctor’s prescription to buy at the pharmacy.