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Minocycline is used to treat acne . The development of acne is favored by male sex hormones (androgens ) . Therefore, men are more frequently affected than women . But also women produce to a certain extent androgens . The hormones stimulate the sebaceous glands to produce more sebum . The excess sebum accumulates and form nodules . These nodules are colonized by bacteria that feed on sebum . They produce waste products that irritate the sebaceous gland and thereby ignite . The result is the typical pimple with head . Minocycline is an antibiotic . It works by killing the acne bacteria . Tetracycline is used to treat mild to moderate forms of inflammatory acne .