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The active ingredient Piroxicam is an analgesic and anti-inflammatory agent selected from the group of oxicams. It counts as aspirin, Ibuprofen and Diclofenac to the group of non-steroidal anti-inflammatory drugs (NSAIDs), but in contrast to this, a long duration of action. Here you can read everything you need to Piroxicam: action, application and exchange and side effects
How Piroxicam acts
Like other NSAIDs inhibit Piroxicam after taking the body the enzyme cyclooxygenase (COX). Cyclooxygenases come before varied in different tissue types and organs and form tissue hormones (prostaglandins). These are, firstly, tissue hormones in various physiological processes involved in the body such as blood clotting, the vasoconstriction and the regulation of gastric acid production. Secondly, certain prostaglandins are formed in inflammatory processes in the body as a messenger: You attract immune cells (to fight eventually penetrated pathogen), allow the tissue to swell (thus the immune cells better immigrate and possible toxins can be transported better) and convey pain stimuli to the brain to convey, so this is attention to the injured part of the body.
Prior to the development of the oxicams, Piroxicam to those heard you had to take NSAIDs two- to three times a day, because the body breaks down this quickly and the duration of action is short. In addition, you had to partially active day on a gram scale to take in order to ensure sufficient potency, but this operation also the degree of side effects in the air.
With Piroxicam succeeded to produce a comparatively potent substance that acts at the same time sufficiently long. Undesirable side effects were reduced and increased taking patient compliance (compliance).
Up, degradation and excretion of Piroxicam
After taking the drug is partially absorbed in the stomach and partly in the intestine. The maximum blood levels are reached after two to three hours. Turning Piroxicam not a tablet, but as a suppository (suppository) at, the highest blood levels can be measured by five to six hours. Because the body partially withdraws the drug by the liver with the bile into the intestine, where it is re-absorbed into the blood, it comes after six to ten hours at a second blood levels rise. This mechanism contributes to the prolonged duration of action of Piroxicam. Much of the ineffective degradation products is excreted through the kidneys into the urine. After about two days, half of the drug is eliminated from the body.
When will Piroxicam used?
The painkillers Piroxicam has been approved for anti-inflammation and pain relief in chronic inflammatory and acutely inflamed rheumatic diseases. It is used as a means of second choice if other NSAIDs can not be applied or not sufficiently effective.
Since the maximum effect of Piroxicam is reached only after five to ten days, a faster anesthetic drug should be administered for the treatment of acute pain.
Usually, the duration of treatment is limited to two weeks, but may be exceeded under a doctor’s supervision.
How Piroxicam is applied
The drug is often used in the form of tablets. Are usual doses of ten to 20 milligrams of Piroxicam once per day during or after a meal. It may be taken with a glass of water and always about the same time each day.
In order to avoid gastrointestinal discomfort the doctor prescribes sometimes additional proton pump inhibitor (for example) or other stomach acid inhibitors (eg, misoprostol).
Piroxicam is in the form of suppositories, as an infusion solution and a cream available.
What are the side effects of Piroxicam?
For more than ten percent of those treated occurs while taking Piroxicam to adverse drug reactions (ADRs) such as heartburn, abdominal pain, nausea, vomiting, flatulence, and minor gastrointestinal bleeding.
With a ten to one hundred patients show Piroxicam side effects like headache, dizziness, tiredness, ringing in the ears (), ulcers in the gastrointestinal tract, stomach irritation, skin rash and increases in liver enzymes and urea blood levels.
What should be considered when taking Piroxicam?
While you are taking Piroxicam should no other NSAIDs (such as aspirin, Diclofenac, Ibuprofen) to be taken, as these also inhibit the COX enzyme and thus compete with Piroxicam.
The risk of bleeding in the digestive tract increases if Piroxicam together with glucocorticoids (“cortisone”), anticoagulants (warfarin, phenprocoumon, aspirin, Clopidogrel, ticagrelor, prasugrel) or drugs for depression (Fluoxetine, Citalopram, Sertraline) is taken.
Piroxicam, the blood levels of the antiepileptic drug Phenytoin and the mood stabilizer lithium increase, so especially at the beginning of the combined application of a closely monitor the blood levels is recommended.
When co-administered NSAIDs may as Piroxicam antagonize the effects of diuretic drugs (diuretics) and high blood pressure medications such as ACE inhibitors (Ramipril, Captopril, Lisinopril) and Sartanen (Candesartan, Irbesartan, Valsartan) and impair kidney function especially in the elderly , This can in extreme cases lead to renal failure.
Since Piroxicam during pregnancy increases the risk of miscarriage and is excreted into breast milk, pregnant and nursing mothers should not take the drug.
Patients who are younger than 18 years or older than 80 years should not take Piroxicam. In patients over 70 years or with existing renal dysfunction may be the Piroxicam dosage must be reduced.
How to obtain drugs with Piroxicam
Pain products containing Piroxicam are prescription in each dose, so can only be purchased with a prescription.
Since when Piroxicam is known?
In 1962, the development of Piroxicam began with the pharmaceutical company Pfizer with the goal of winning a long-acting and potent NSAIDs. Almost two decades later, Piroxicam was approved in 1980 as the first representative of the class of oxicams in Europe.