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Sulfasalazine is used for rheumatism (rheumatoid arthritis, RA), a disease in which the immune system attacks the body depends (autoimmune disease). Our immune system protects the body against diseases. It detects foreign cells (bacteria) or changes in body cells (cancer cells) and combats them. In rheumatoid arthritis, these reactions are misdirected. The immune system fights falsely also endogenous tissue and tried to destroy it. As part of this, there is a severe chronic joint inflammation, which is accompanied by pain and eventually leads to the destruction of the joints. Therefore, you have to regulate the immune system. Sulfasalazine is a basic antirheumatic. Based drugs are used for a lifetime in order to keep the inflammation permanently at bay. The mechanism of action of Sulfasalazine is not precisely known. It is believed, however, that it suppresses the immune response. When the immune system only works limited, the vicious cycle of inflammation is interrupted and inflammation, swelling and pain diminish. Autoimmune diseases are indeed incurable until now. However, treated early can prevent the destruction of the tissue and maintain the ability to function.