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Tretinoin comes from the Vitamin A . It normalizes the growth and formation of skin and mucous membrane cells and reduces inflammation . Tretionoin regulates especially the lack of skin renewal in acne patients . The superficial stratum corneum is also loosened up , and redundant cells can be more easily exfoliated . In the first weeks of therapy the acne blooms on in earnest. Nevertheless, the treatment must be continued consistently . After treatment, a long-term improvement in the appearance of the skin sets . Tretinoin is used externally in mild to severe forms of acne .